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. Author manuscript; available in PMC: 2014 Mar 13.
Published in final edited form as: Nature. 2013 Jul 31;501(7466):237–241. doi: 10.1038/nature12427

Figure 2. Blunting of antiviral immune responses in mice expressing HCV entry factors augments HCV RNA replication.

Figure 2

(a–d) Bioluminescence kinetic of BiCre-Jc1 infected Rosa26-Fluc mice expressing all four HCV entry factors and entry-factor negative controls (a) with fully intact innate immune system or impaired in (b) PKR, MAVS, (c) IRF1, IRF3, IRF7, IRF9, (d) IFNαβR or STAT1. (e) HCV RNA levels in the serum of 4hEF mice or 4hEF mice deficient in STAT1, IRF1, IRF3, IRF7, MAVS or IRF9 6 weeks post infection with BiCre-Jc1.