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. 2013 Dec 11;4:446. doi: 10.3389/fimmu.2013.00446

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Copyright © 2013 Guimont-Desrochers and Lesage.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Positioning pre-mNK cells in the NK-cell differentiation pathway. NK-cell differentiation is a multi-step process, wherein cellular intermediates can be distinguished based on the acquisition and loss of the expression of specific cell surface antigens, in mice. Pre-NKP cells represent the earliest defined mNK cell-committed progenitor. Here, pre-mNK cells are positioned as a cellular intermediate following iNK cells and preceding mNK cells. Question marks indicate differentiation steps that remain to be experimentally verified. The thymic-derived pathway is also depicted.