Table 1.
pre-mNK cells | pDC | mNK cells | Activated NK cells | ||
---|---|---|---|---|---|
DIFFERENTIATION | |||||
Id-2 | Yes | No | Yes | Yes | |
IL-15 | Yes | No | Yes | Yes | |
γc Cytokines | Yes | No | Yes | Yes | |
Flt3L | + | +++ | ++ | ||
PU.1 | No | Yes | No | No | |
RelB | Yes | Yes | No | No | |
IRF8 | Partially | Yes | No | No | |
FUNCTION | |||||
IFN-γ production | +++ | − | + | +++ | |
IL-12 production | + | ++ | − | − | |
IFN-α production | − | +++ | − | − | |
Killing mechanism | TRAIL and NKG2D-dependent | No | Perforin/granzyme-dependent | Perforin/granzyme-dependent | |
Cytotoxic activity | +++ | − | + | +++ | |
Antigen presentation | + | + | − | + | |
ANTIGENIC PHENOTYPE | In vivo | In vitro | |||
CD11c | Low | Low | No/low | No/low | Low |
B220 | High | High | − | − | High |
CD49b | + | − | + | + | + |
CD122 | + | − | + | + | + |
NK1.1 | + | − | + | + | + |
CD43 | + | −/+ | +++ | +++ | +++ |
Ly108 | +++ | −/+ | − | − | − |
CD27 | High | − | Low/high | Low/high | Low/high |
CD11b | Low/high | − | Low/high | Low/high | Low/high |
MHC II | + (in LNs)/−(in spleen) | + | − | + | + |
CD69 | + | − | − | + | + |
CD86/CD80 | + (in LNs)/−(in spleen) | + | − | − | − |
CHARACTERISTICS | |||||
Proliferation | ++++ | + | + | ++ |