Table 2.
Substance | Medication | Target | Action |
---|---|---|---|
Cocaine | Disulfiram Doxazosin Modafinil Topiramate Methylphenidate SR-METH/AMPH |
Dopamine β-hydroxylase α1 receptors DAT, α receptors AMPA/Kainate, GABA NET, DAT NET, DAT |
↓ NE, ↑ DA ↓ cocaine-induced DA ↑ DA, Glutamate, Orexin, ↓ GABA ↓ Glutamate, ↑ GABA ↑ NE, ↑ DA ↑ NE, ↑ DA |
METH/AMPH | Bupropion Naltrexone Rivastigmine Topiramate Perindopril Modafinil Methylphenidate |
DAT, NET μ opioid receptors Acetylcholinesterase AMPA/Kainate, GABA ACE DAT, α receptors NET, DAT |
↑ DA, ↑ NE ↓ μ receptor activation ↑ acetylcholine ↓ Glutamate, ↑ GABA ↑ DA, ↓ NE ↑ DA, Glutamate, Orexin, ↓ GABA ↑ NE ↑ DA |
AMPA-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, ACE-angiotensin converting enzyme, DA-dopamine, NE-norepinephrine, GABA-γ aminobutyric acid, DAT-dopamine transporter, NET-norepinephrine transporter, SR-METH-sustained release methamphetamine, SR-AMPH-sustained release amphetamine.