Table-I.
Effect of nicotinic acid on lipid profile of hypercholesterolemic, non diabetic and hypercholesterolemic, diabetic rats
| Parameters |
Group 1
(Control A on feed only) |
Group 2
(Control B on feed + Olive Oil) |
Group 3
(Diabetic C on feed + Olive Oil) |
Group 4
(Hypercholesterolemic) |
Group 5
(Hypercholesterolemic and Diabetic) |
P- statistics & P-value
|
F-statistics & F-value
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 21 | Day 42 | Day 1 | Day 21 | Day 42 | Day 1 | Day 21 | Day 42 | Day 1 | Day 21 | Day 42 | Day 1 | Day 21 | Day 42 | Groups & P-value |
Days & P-value |
Interaction of Groups & P-value |
Groups & F-value |
Days & F-value |
Interaction of Groups & F-value |
|
| Total cholesterol (mg/dl) |
142±1.7 | 141±1.8 | 142±1.7 | 146±2.8 | 144±1.96 | 142±2.1 | 148±0.96 | 148±1.03 | 147±0.98 | 213±3.02 | 165±4.47 | 149±3.86 | 217±3.33 | 171±1.88 | 161±1.63 | 0.000 | 0.000 | 0.000 | 983.0 | 4422.7 | 1444.4 |
| HDL-cholesterol (mg/dl) |
48±1.4 | 49±1.9 | 48.23±1.16 | 48±1.8 | 47.8±1.8 | 47.8±1.48 | 44±1.04 | 43.4±1.19 | 42±1.88 | 29.4±1.5 | 53.7±1.7 | 57.5±1.36 | 21.6±2.7 | 51.6±2.6 | 56.5±1.9 | 0.000 | 0.000 | 0.000 | 25.74 | 4004.341 | 1838.649 |
| LDL-cholesterol (mg/dl) |
70±3.16 | 68±5.5 | 70±.3.04 | 70±4.0 | 72±6.6 | 69±3.31 | 75±0.95 | 74±1.16 | 74±1.6 | 135±1.8 | 79±4.22 | 67±5.2 | 147±5.72 | 94±3.10 | 78±4.02 | 0.000 | 0.000 | 0.000 | 238.6 | 7105.71 | 2508.36 |
| Triglycerides (mg/dl) |
132±5.14 | 132±4.33 | 132±5.2 | 132±3.9 | 132±4.24 | 130±4.4 | 130±31.2 | 138±1.65 | 138±1.42 | 225±1.9 | 169±4.5 | 131±1.62 | 229±5.6 | 166±3.6 | 128±1.95 | 0.000 | 0.002 | 0.000 | 432 | 8798.15 | 3119.64 |
| Total Lipids(TL) | 546±3.78 | 496±157 | 548±2.19 | 551±3.47 | 550±3.32 | 548±3.87 | 557±2.70 | 555±3.36 | 554±3.56 | 982±22.7 | 622±11.03 | 449±34 | 997±10.4 | 786±11.3 | 548±48.4 | 0.000 | 0.000 | 0.000 | 172.22 | 2088.58 | 776.27 |
Repeated measure ANOVA.
Significant value (P value) P< 0.05
Overall significant difference in serum Total Cholesterol (TC), serum High Density Lipoprotein (HDL), serum Triglyceride (TG), serum Low Density Lipoprotein (LDL) and serum Total Lipids (TL) mg/dl was observed in all the groups as compared to the two Control Groups as well as the Diabetic C Group.