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UGT1A4 and UGT1A8 genetic associations with ABT-751 pharmacokinetics. Associations between (a) UGT1A8 rs6431558 and glucuronidation metabolic ratios (ABT-751G AUC/ABT-751 AUC) and (b) UGT1A4*2 and ABT-751 Ctrough. Natural log-transformed data are shown. Horizontal lines represent the mean value of the log-transformed data.
