Table 2.

UGT and SULT variants selected for genotyping

Gene	Rs number	Location	Variant	Base change	Genotyping method
UGT1A8	rs1042597	Exonic	UGT1A8*2	518 C>G	SBE-DHPLC
	rs1042605	Exonic	UGT1A8*1a	765 A >G	SBE-DHPLC
	rs1551285	Intronic	–	C> A	SBE-DHPLC
	rs6431558	Intronic	–	T >C	SBE-DHPLC
UGT1A4	rs6755571	Exonic	UGT1A4*2	70 C> A	SBE-DHPLC
	rs12468274a	Exonic	–	448 T>C	SBE-DHPLC
	rs2011404	Exonic	–	471 T>C	SBE-DHPLC
	rs871514	Intronic	–	T >C	PCR-sequencing
	rs13401281	Intronic	–	T >G	PCR-sequencing
UGT1A1	rs4124874	5′-UTR	–	– 3279 G> T	SBE-DHPLC [22]
	rs10929302	5′-UTR	–	– 3156 G>A	SBE-DHPLC [22]
	rs4624373	5′-UTR	–	– 2951 A >G	SBE-DHPLC
	rs3755319	5′-UTR	–	– 1352 A >C	SBE-DHPLC
	rs8175347	Promoter	UGT1A1*28	(TA)5, 6, 7, 8	PCR-sizing (GeneScan) [22]
UGT2B7	rs62298861	Intronic	–	Int1 + 985 A >G	SBE-DHPLC [23]
	rs7668258	Promoter	–	– 161 T>C	SBE-DHPLC [23]
SULT1A1	rs3760091b	Promoter	–	– 624 G>C	Hebbring et al. [11]
	rs750155	Promoter	–	– 396 G> A	Hebbring et al. [11]
	rs9282861	Exonic	SULT1A1*2	638 G> A	Hebbring et al. [11]
	rs1801030	Exonic	SULT1A1*3	667 A >G	Hebbring et al. [11]
	Copy number (2, 3, 4, 5)	–	–	Copy number (2, 3, 4, 5)	Hebbring et al. [11]

LD, linkage disequilibrium; SBE-DHPLC, single base extension-denaturing high-performance liquid chromatography; SULT, sulfotransferase; UGT, UD-Pglucuronosyltransferase; 5′-UTR, 5′-untranslated region.

^aIn LD with UGT1A4*3.

^bIn LD with SULT1A1*2.