Table 1.

In vitro stability of modified aptamers.

Modification	Aptamer	Half-Life	Reference
Unmodified RNA	Trypanosome	<1 s	[10]
2′-FP	TTA1	42 h	[31] out of order
2′OMe	TTA1	49 h	[31] out of order
LNA	TTA1	53–72 h	[31]
2′FP & 2′NH2	Trypanosome	36 h	[10]
2′FP	Trypanosome	81 h	[10]
2′NH2	Trypanosome	367 h	[10]
LNA	sgc8c (c8L3)	3 h	[32]out of order
2′FP	RET Receptor Tyrosine Kinase	6 h	[33]out of order

Notes: Abbreviations: 2′FP: 2′-Fluoropyrimidines; 2′OMe: 2′O-methyl: LNA: Locked nucleic acid; 2′NH₂: 2′-aminopyrimidine.