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. 2013 Sep;73(9):874–889. doi: 10.1055/s-0033-1350713
No. Recommendations GR LoE Sources
* Data on the effectiveness of consolidation or maintenance therapy to increase progression-free survival (PFS) is only available for bevacizumab (see 8.6.)
8.5. The first-line chemotherapy for patients with advanced ovarian cancer (II b-IV) must consist of carboplatin AUC5 and paclitaxel 175 mg/m2 for 3 h i. v. over a total of 6 cycles, with one cycle every 3 weeks. A 1++ Guidelines: 118, 119 Primary studies: 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131
8.6. Additional therapy with bevacizumab can be considered in patients with advanced ovarian cancer (IIIB-IV). 0 1+ Primary studies: 132, 133
8.7. Changes in dose density or intensity should only be done as part of a clinical trial. B 1+ Guidelines: 2 Primary studies: 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146
8.8. No maintenance or consolidation therapies must be carried out after primary therapy has been completed.* A 1+ Primary studies: 132, 133, 147, 148, 149, 150, 151, 152, 153, 154
8.9. Systematic recording of the patientʼs quality of life can be helpful to identify difficulties during treatment. CC