Figure 5.

Tumor growth control in vivo. Growth kinetics of CT26 tumors in animals following injection of TLR ligands, their combinations, or Irinotecan. Therapy was performed by repetitive i.p. application of substances twice a week for a total of six times (n = 7). Control animals received equivalent volumes of PBS (n = 7). Values are given as mean ± SEM. None of the treatments reached statistical significance (P values d17 versus control: R848 0.232; Taxol 0.655; LPS 0.705; Irinotecan 0.340; R848 + Taxol 0.252; R848 + LPS 0.680; Taxol + LPS 0.789).