Table 4.
Association of polymorphisms with atherogenic index.
| SNP | Medium risk AI | P | High risk AI | P |
|---|---|---|---|---|
| ORa (CI) | ORa (CI) | |||
| IRS1 rs1801279 | ||||
| Log additive | 1.00 (0.68, 1.47) |
0.99 | 1.24 (0.49, 3.13) |
0.65 |
|
| ||||
| TCF7L2 rs12255372 | ||||
| Log additive | 0.95 (0.76, 1.19) |
0.67 | 1.15 (0.64, 2.08) |
0.63 |
|
| ||||
| TCF7L2 rs7903146 | ||||
| Log additive | 0.93 (0.76, 1.15) |
0.51 | 1.35 (0.82, 2.21) |
0.24 |
|
| ||||
| PPARG rs1801282 | ||||
| Log additive | 0.81 (0.65, 1.01) |
0.06 | 0.89 (0.48, 1.65) |
0.71 |
|
| ||||
| ADRB1 rs1801253 | ||||
| Log additive | 1.16 (0.91, 1.47) |
0.22 |
2.52
(1.54, 4.15) |
<0.0001* |
|
| ||||
| HHEX rs5015480 | ||||
| Log additive | 1.03 (0.88, 1.22) |
0.68 | 1.24 (0.82, 1.87) |
0.30 |
Adjusted for age, sex, BMI, disease status, and ancestry percentage. IA Low risk was the reference category. *Bonferroni corrected P value threshold P ≤ 0.004.
Bold text denotes significant P values (<0.05).