Table 3. Time to progression and overall survival by blood DPD enzyme level.

Median blood DPD level (%)	Endpoint	n	Events	Point estimate	90% CI
≤169	Median TTP	7	7	1.7 mon	1.6-5.2 mon
	3-mon rate			23%	0%-51%
	6-mon rate			0%	0%-22%
>169	Median TTP	6	6	1.5 mon	0.4-8.0 mon
	3-mon rate			37%	4%-71%
	6-mon rate			26%	0%-57%
≤169	Median OS	7	7	7.1 mon	5.7-16.3 mon
	3-mon rate			35%	4%-66%
	6-mon rate			6%	0%-28%
>169	Median OS	6	5	14.9 mon	0.0-29.6 mon
	3-mon rate			54%	20%-87%
	6-mon rate			29%	0%-60%

TTP = time to progression; OS = overall survival; DPD = dihydropyrimidine dehydrogenase; CI = confidence interval.