Table 5.
Estimates and comparisons of central corneal thickness for subjects without and with edema.
| Without Edema | With Edema | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean (95% CI) | P-value1 | N | Mean (95% CI) | P-value2 | Mean (95% CI) | P-value3 | N | Mean (95% CI) | N | Mean (95% CI) | Mean (95% CI) | P-value 4 | |
| FECD | Controls | Unaffected family | Difference | Controls | Unaffected family | Difference | ||||||||
| 0 | 551 | 558 (554, 562) | -- | 121 | 558 (548, 569) | -- | 0 (−11, 12) | 0.96 | 0 | -- | 0 | -- | -- | -- |
| Index Cases | Affected family | Difference | Index Cases5 | Affected family5 | Difference | |||||||||
| 1 to 3 | 12 | 576 (557, 595) | 0.06 | 182 | 570 (563, 576) | 0.06 | −7 (−27, 14) | 0.52 | 4 | 629 (586, 672) | 5 | 592 (575, 608) | −37 (−83, 9) | 0.11 |
| 4 | 55 | 589 (577, 600) | <0.001 | 166 | 571 (560, 581) | 0.09 | −18 (−33, −3) | 0.02 | 9 | 628 (595, 660) | 12 | 626 (593, 659) | −1 (−48, 45) | 0.95 |
| 5 | 91 | 612 (603, 620) | <0.001 | 160 | 595 (583, 607) | <0.001 | −17 (−31, −2) | 0.02 | 0 | -- | 0 | -- | -- | -- |
| 6 | 0 | -- | -- | 0 | -- | -- | -- | -- | 121 | 649 (640, 658) | 121 | 630 (619, 641) | −19 (−33, −4) | 0.01 |
P-value associated with comparing the mean CCT between each index FECD grade group to controls for subjects without clinically apparent edema.
P-value associated with comparing the mean CCT between each affected family member FECD grade group to unaffected family members for subjects without clinically apparent edema.
P-value associated with comparing the mean CCT between affected family members to index cases or unaffected family members to controls for subjects without clinically apparent edema.
P-value associated with comparing the mean CCT between affected family members to index cases for subjects with clinically apparent edema.
Subjects with edema at FECD grades 1–4 represent individuals with focally dense guttae observed to also have clinically evident edema on slit lamp examination. Subjects scored as FECD grade 5 and also noted to have clinically observed edema were equivalent to a FECD grade 6 and were classified accordingly.