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. 2013 Jul 15;20(6):549–565. doi: 10.1093/dnares/dst030

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© The Author 2013. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 2. — DNA methylation dynamics during germ cell development. (A) k-means clustering of DNA methylation profiles of germ cells, stem cells and adult organs. DNA methylation levels of the CCGG segments are represented as a heat map (unmethylated segments in dark blue, M-value = 6.00; highly methylated segments in dark red, M-value = –6.00). (B) Changes in global DNA methylation levels during PGC development. The M-value was calculated for each sample and is shown as a box plot. The bottom and top of the boxes are the 25th and 75th percentile, respectively.