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. 2013 Jul 15;20(6):549–565. doi: 10.1093/dnares/dst030

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© The Author 2013. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 3. — Discovery of large, contiguous genomic regions with low DNA methylation modifications in male germ cells. The methylation profiles of genomic DNA along the mouse X chromosome. Samples used for the analysis are indicated in each figure. The M-value of each CCGG segment obtained from the analysis of each sample DNA is plotted on the mouse X chromosome (grey dots). The y-axis represents the M-value; log₂(HpaII/MspI). The black line was drawn using DNAcopy, a circular binary segmentation programme obtained from http://www.bioconductor.org/packages/2.3/bioc/html/DNAcopy.html.³² Red dots represent CCGG segments belonging to Cluster 4. Double-headed arrows indicate the position of the Xmr gene cluster.