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. 2013 Aug 8;20(6):605–621. doi: 10.1093/dnares/dst034

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© The Author 2013. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — The chromosomal locations of genes and CpG islands differentially methylated in the MRL/MpJ mouse. (A) The genes and CpG islands that are differentially methylated in the three examined tissues: heart, liver, and spleen. PT - DNA methylation peak mapped to a primary transcript, kb—distance in kb is given if the methylation peak is located out of the range 5000 bp upstream and 1000 bp downstream the feature. (B) The genes and CpG islands differentially methylated in the heart, liver, and spleen. The genes displaying substantially higher and lower methylation degree in the MRL/MpJ mouse are marked red (hypermethylated, grey in the print) and blue (hypomethylated, black in the print), respectively. The values and genomic coordinates of the DNA methylation peaks as well as the descriptions of mapped of genes are listed in Supplementary Table S1. Heart vs. liver analysis singled out the genes and CpG islands, which have different methylation status in the heart than in the liver of the MRL/MpJ, but not the C57BL/6J, mouse. (see the chapter: ‘Genes with similar DNA methylation status in the heart and liver of the MRL/MpJ but not the C57BL/6J mouse’).