Figure 4.

Genome-wide DNA methylation profiles display lower inter-tissue diversification in the MRL/MpJ than in the C57BL/6J mouse. Inset: Similarly, we observed lower inter-tissue diversification of genome-wide DNA methylation profiles reported by Liang et al.⁴⁴ in embryos and newborns than in adults (with the exception for the correlations between the heart and brain). The inter-tissue correlations between pairs of genomic DNA methylation profiles were determined using Pearson's correlations coefficients. All Pearson's correlation coefficients were statistically significant with P-values of <0.0001. Pearson's correlation coefficients were calculated for the pairs of genomic DNA methylation arrays obtained in this study: heart–spleen, spleen–liver, and heart–liver for both the MRL/MpJ and C57BL/6J mouse. Analogically, Pearson's correlation coefficients were determined for the genomic DNA methylation profiles in different tissues of murine embryos, newborns, and adults reported by Liang et al.⁴⁴ The microarray data were extracted from the dataset deposited in the GEO database under the accession number GSE21415. The Pearson's correlation coefficients shown in the inset were determined for the average values obtained from two biological replicates, but similar trends were found in the correlations determined for individual animals (not shown).