Table 3.
Association of Adipose Tissue Density at Baseline in Quintiles With Mortality, AGES-Reykjavik
| No. at Risk | No. of Events | Rate Per 1,000 Person-y | Model 1*, HR (95% CI) | Model 2†, HR (95% CI) | Model 3‡, HR (95% CI) | Model 4§, HR (95% CI) | |
|---|---|---|---|---|---|---|---|
| VAT | |||||||
| Women | |||||||
| Q1 | 585 | 103 | 27.0 | 1.00 | 1.00 | 1.00 | 1.00 |
| Q2 | 585 | 102 | 26.4 | 0.87 (0.66–1.15) | 1.03 (0.78–1.38) | 1.07 (0.80–1.43) | 1.04 (0.78–1.39) |
| Q3 | 585 | 101 | 25.9 | 0.84 (0.64–1.10) | 1.10 (0.81–1.49) | 1.13 (0.83–1.53) | 1.02 (0·75–1.39) |
| Q4 | 585 | 112 | 28.9 | 0.87 (0.67–1.14) | 1.23 (0.88–1.71) | 1.24 (0.89–1.73) | 1.17 (0.84–1.63) |
| Q5 | 584 | 151 | 40.8 | 1.25 (0.97–1.61) | 1.88 (1.31–2.69) | 1.92 (1.34–2.74) | 1.65 (1.15–2.36) |
| p value for trend | .007 | .001 | .001 | .01 | |||
| Men | |||||||
| Q1 | 441 | 112 | 40.7 | 1.00 | 1.00 | 1.00 | 1.00 |
| Q2 | 442 | 123 | 44.7 | 1.12 (0.87–1.45) | 1.13 (0.87–1.47) | 1.19 (0.91–1.55) | 1.14 (0.87–1.49) |
| Q3 | 441 | 128 | 46.5 | 1.09 (0.85–1.41) | 1.10 (0.84–1.45) | 1.18 (0.90–1.55) | 1.07 (0.81–1.41) |
| Q4 | 442 | 125 | 46.0 | 1.03 (0.80–1.33) | 1.04 (0.78–1.40) | 1.17 (0.87–1.58) | 1.02 (0.75–1.38) |
| Q5 | 441 | 150 | 56.6 | 1.20 (0.94–1.54) | 1.23 (0.88–1.71) | 1.28 (0.92–1.79) | 1.06 (0.75–1.49) |
| p value for trend | .59 | .67 | .69 | .88 | |||
| SAT | |||||||
| Women | |||||||
| Q1 | 585 | 84 | 20.7 | 1.00 | 1.00 | 1.00 | 1.00 |
| Q2 | 584 | 88 | 22.6 | 0.96 (0.71–1.29) | 0.90 (0.67–1.22) | 0.89 (0.66–1.20) | 0.81 (0.60–1.10) |
| Q3 | 585 | 88 | 23.0 | 0.96 (0.71–1.30) | 0.88 (0.65–1.20) | 0.88 (0.65–1.20) | 0.81 (0.59–1.10) |
| Q4 | 585 | 116 | 30.7 | 1.28 (0.96–1.69) | 1.14 (0.85–1.53) | 1.16 (0.87–1.57) | 0.98 (0.72–1.32) |
| Q5 | 585 | 193 | 53.8 | 1.82 (1.40–2.37) | 1.56 (1.15–2.11) | 1.48 (1.09–2.00) | 1.14 (0.82–1.58) |
| p value for trend | <.001 | <.001 | .001 | .08 | |||
| Men | |||||||
| Q1 | 441 | 112 | 40.3 | 1.00 | 1.00 | 1.00 | 1.00 |
| Q2 | 442 | 112 | 40.1 | 1.00 (0.77–1.30) | 1.11 (0.84–1.45) | 1.14 (0.87–1.49) | 1.06 (0.80–1.39) |
| Q3 | 441 | 118 | 42.7 | 1.05 (0.81–1.36) | 1.22 (0.92–1.61) | 1.21 (0.91–1.61) | 1.10 (0.82–1.46) |
| Q4 | 442 | 137 | 50.9 | 1.15 (0.90–1.48) | 1.43 (1.07–1.91) | 1.51 (1.12–2.03) | 1.27 (0.93–1.73) |
| Q5 | 441 | 159 | 61.1 | 1.28 (1.01–1.63) | 1.70 (1.24–2.35) | 1.64 (1.18–2.26) | 1.25 (0.88–1.77) |
| p value for trend | .19 | .01 | .02 | .59 | |||
Notes: AGES-Reykjavik = Age, Gene/Environment Susceptibility-Reykjavik; HR = hazard ratio; SAT = subcutaneous adipose tissue; VAT = visceral adipose tissue.
*Adjusted for age and education.
†Adjusted for Model 1 covariates plus body mass index, area of respective fat depot, and sagittal diameter.
‡Adjusted for Model 2 covariates plus smoking status, drinking status, physical activity, comorbid conditions, and time of computed tomography scan.
§Adjusted for Model 3 covariates plus weight history (% change from midlife) and prior hospitalization.