Table 4.
Association of Adipose Tissue Density at Baseline in Quintiles With Adipocytokines
| Mean (SE) | N | Q1 | Q2 | Q3 | Q4 | Q5 | p Value for Trend |
|---|---|---|---|---|---|---|---|
| Women, Health ABC | |||||||
| VAT | |||||||
| IL-6, pg/mL | 1,313 | 2.32 (0.14) | 2.43 (0.12) | 2.31 (0.12) | 2.14 (0.12) | 2.43 (0.14) | .38 |
| Leptin, ng/mL | 1,369 | 23.1 (0.82) | 23.3 (0.70) | 21.7 (0.68) | 19.7 (0.70) | 17.8 (0.82) | .001 |
| Adiponectin, μg/mL | 1,378 | 12.1 (0.47) | 12.1 (0.40) | 12.7 (0.40) | 13.7 (0.41) | 16.7 (0.48) | .001 |
| CRP, μg/mL | 1,374 | 3.51 (0.34) | 3.33 (0.29) | 3.15 (0.28) | 3.00 (0.29) | 3.32 (0.34) | .81 |
| SAT | |||||||
| IL-6, pg/mL | 1,313 | 2.47 (0.12) | 2.07 (0.12) | 2.33 (0.12) | 2.24 (0.12) | 2.53 (0.13) | .06 |
| Leptin, ng/mL | 1,369 | 22.2 (0.70) | 21.4 (0.69) | 21.6 (0.67) | 20.2 (0.68) | 20.3 (0.74) | .22 |
| Adiponectin, μg/mL | 1,378 | 12.5 (0.42) | 12.8 (0.41) | 12.4 (0.40) | 13.8 (0.41) | 15.8 (0.44) | <.001 |
| CRP, μg/mL | 1,374 | 3.94 (0.29) | 2.96 (0.29) | 2.91 (0.28) | 3.24 (0.28) | 3.26 (0.31) | .08 |
| Men, Health ABC | |||||||
| VAT | |||||||
| IL-6, pg/mL | 1,280 | 2.65 (0.13) | 2.29 (0.12) | 2.29 (0.12) | 2.43 (0.12) | 2.60 (0.14) | .07 |
| Leptin, ng/mL | 1,325 | 9.39 (0.41) | 8.44 (0.37) | 7.90 (0.36) | 7.42 (0.37) | 6.47 (0.42) | <.001 |
| Adiponectin, μg/mL | 1,333 | 7.22 (0.37) | 8.91 (0.33) | 8.07 (0.32) | 10.2 (0.33) | 12.8 (0.37) | <.001 |
| CRP, μg/mL | 1,332 | 3.91 (0.34) | 2.41 (0.30) | 2.33 (0.30) | 2.52 (0.30) | 2.39 (0.34) | .003 |
| SAT | |||||||
| IL-6, pg/mL | 1,280 | 2.26 (0.13) | 2.36 (0.12) | 2.46 (0.17) | 2.53 (0.12) | 2.65 (0.13) | .37 |
| Leptin, ng/mL | 1,325 | 7.92 (0.39) | 8.39 (0.36) | 8.01 (0.35) | 7.59 (0.36) | 7.70 (0.39) | .60 |
| Adiponectin, μg/mL | 1,333 | 8.25 (0.36) | 9.32 (0.33) | 8.57 (0.33) | 9.20 (0.33) | 11.8 (0.37) | <.001 |
| CRP, μg/mL | 1,332 | 2.99 (0.33) | 2.60 (0.30) | 2.78 (0.30) | 2.79 (0.30) | 2.39 (0.33) | .76 |
| Women, AGES-Reykjavik | |||||||
| VAT | |||||||
| CRP, μg/mL | 2,923 | 4.01 (0.30) | 3.59 (0.26) | 3.73 (0.25) | 3.53 (0.26) | 3.62 (0.30) | .79 |
| SAT | |||||||
| CRP, μg/mL | 2,923 | 3.68 (0.27) | 4.11 (0.26) | 3.47 (0.26) | 3.73 (0.26) | 3.49 (0.28) | .41 |
| Men, AGES-Reykjavik | |||||||
| VAT | |||||||
| CRP, μg/mL | 2,206 | 3.32 (0.36) | 3.76 (0.32) | 3.63 (0.31) | 3.49 (0.32) | 4.05 (0.37) | .68 |
| SAT | |||||||
| CRP, μg/mL | 2,206 | 3.44 (0.37) | 3.34 (0.32) | 4.01 (0.31) | 3.56 (0.32) | 3.90 (0.36) | .57 |
Notes: Least-square means adjusted for body mass index and area of respective fat depot. AGES-Reykjavik = Age, Gene/Environment Susceptibility-Reykjavik; CRP = C-reactive protein; Health ABC = Health, Aging, and Body Composition; NHPs = nonhuman primates; SAT = subcutaneous adipose tissue; VAT = visceral adipose tissue.