Table 5.
Relationships Between Adipose Tissue Density, Biomarkers, and Adipose Gene Expression in NHPs
| Variable | VAT Density | SAT Density | ||
|---|---|---|---|---|
| r | p Value | r | p Value | |
| Serum biomarkers | ||||
| sICAM-1 | .22 | .31 | −.08 | .71 |
| TNF-α | .01 | .98 | −.17 | .42 |
| MCP-1 | .36 | .08 | .29 | .17 |
| IL-6 | −.06 | .77 | −.02 | .93 |
| CRP | −.01 | .96 | .18 | .40 |
| Leptin | −.81 | <.001 | −.76 | <.001 |
| Adiponectin | .45 | .03 | .23 | .28 |
| Glucose | −.25 | .23 | −.19 | .39 |
| Insulin | −.09 | .67 | −.12 | .58 |
| Gene expression | ||||
| SAT-CD68 | −.19 | .36 | −.03 | .89 |
| SAT-CD3 | .03 | .89 | .04 | .87 |
| SAT-CD4 | −.21 | .32 | −.04 | .84 |
| SAT-IL-6 | −.21 | .32 | −.25 | .24 |
| SAT-TNF-α | .01 | .96 | .00 | .99 |
| SAT-MCP-1 | −.25 | .24 | −.10 | .63 |
| SAT-leptin | −.38 | .07 | −.47 | .02 |
| SAT-adiponectin | .14 | .51 | .03 | .89 |
| VAT-CD68 | −.21 | .32 | −.07 | .73 |
| VAT-CD3 | .02 | .91 | .09 | .66 |
| VAT-CD4 | −.02 | .92 | .13 | .54 |
| VAT-IL-6 | −.25 | .24 | −.02 | .93 |
| VAT-TNF-α | −.01 | .97 | .06 | .78 |
| VAT-MCP-1 | .10 | .65 | .17 | .43 |
| VAT-leptin | −.63 | .001 | −.60 | .002 |
| VAT-adiponectin | .19 | .37 | .18 | .41 |
Notes: CRP = C-reactive protein; NHPs = nonhuman primates; SAT = subcutaneous adipose tissue; VAT = visceral adipose tissue.