Figure 6. HOCl reverses markers of epidermal aging.

Data from control 2-day-old mice and 18-month-old mice treated topically with H₂O or HOCl for 14 days (n = 7–11 for each 18-month-old treatment group; n = 3 for 2-day-old mice). (A) p16^INK4A immunostaining. (B) Quantification of p16^INK4A immunostaining. *P = 0.03. (C) Relative mRNA levels of Rad50. *P = 0.001. Black bars represent HOCl treatment. Original magnification, ×20. Representative immunohistochemistry images for each group are shown. Data are presented as the average ± SEM.