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. 2013 Nov 15;123(12):5342–5350. doi: 10.1172/JCI72117

Figure 4. Cell-type–specific, time-dependent control of local and long range signaling is detected using DREAMM in anesthetized rats.

Figure 4

Time-dependent DREAMM responses after (A) Pdyn- and (B) Penk-expressing MSN inhibition (P = 0.05; relative increase [red] and decrease [blue] in FDG uptake) in sagittal planes and corresponding images from the Paxinos rat brain atlas. Individual subject voxel values in the VTA showing that Pdyn-MSN inhibition significantly increases FDG uptake at 1 minute (P = 0.002) and decreases FDG uptake at 30 minutes (P = 0.03) (C) in comparison with vehicle condition, while Penk-MSN inhibition does not (D). CB, cerebellum; IC, inferior colliculus; AOP, anterior olfactory nucleus; VLL, ventral nucleus of lateral lemniscus; PN, pontine nuclei; RN, reticular nuclei; VC, visual cortex; RS, retrosplenial cortex; CPu, caudate putamen; LPO, lateral preoptic area; LH, lateral hypothalamus; TH, thalamus; BN, brainstem nuclei. *P < 0.05; **P < 0.01.