Figure 6. Unilateral inhibition of spatially overlapping Pdyn- and Penk-expressing neurons in NAcSh of freely moving rats leads to changes in distinct neural circuits.

(A) Pdyn-MSN inhibition (n = 6) increased FDG uptake in specific corticolimbic regions including the Ent, DI, CG, and MEA as well as VP/HDB as visualized in coronal, sagittal and horizontal planes and (B) as plotted as percentage change in signal response *P < 0.05; **P < 0.01. (C) Penk-MSN inhibition (n = 5) led to profound activation of the DI, medial orbital prefrontal cortices (mOR and mPFC), HP circuit, amygdala, VP, and decreased activity of SC, and Pir, and GP, as visualized in coronal, sagittal and horizontal planes and (D) as plotted as percentage change in signal response. *P < 0.05; **P < 0.01. Data represent mean ± SEM.