Figure 8. Model for (dys)regulation of kidney filter function by TRPC5.

Top-down view of podocyte interdigitating FPs composed of parallel actin bundles. TRPC5 activation in response to injury leads to Rac1 activation (Rac1-GTP) and synaptopodin degradation. These events promote podocyte cytoskeletal remodeling. Loss of filter integrity ensues, leading to albuminuria, a potentially reversible condition. TRPC5 inhibition therefore emerges as a therapeutic strategy for the stabilization of the human filter barrier.