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. 2013 Nov 15;123(12):5334–5341. doi: 10.1172/JCI70395

Figure 2. Reduced Pdyn mRNA in the PAC and concomitant sensitization of a neural stress marker induced in rats with chronic heroin self-administration.

Figure 2

(A) Rodent PAC schematic and in situ hybridization image of Pdyn in the PAC. Scale bar: 2 mm. (B) Lever-pressing behavior (active versus inactive lever presses) of rats receiving heroin or saline euthanized 24 hours after last self-administration session. Data shown as mean ± SEM. *P < 0.05 between active lever (AL) and inactive lever (IL) presses of animals receiving heroin. #P < 0.05 in active lever presses between heroin and saline animals. (C) Reduction of PAC-Pdyn mRNA expression in rats 24 hours after final heroin self-administration session versus saline animals. Data represent mean ± SEM, fold change difference. *P < 0.05. (D) Increased Crf mRNA expression in the CeA 24 hours following heroin self-administration. Values are expressed in DPM/mg (mean ± SEM). *P < 0.05.