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. 2013 Nov 15;123(12):5334–5341. doi: 10.1172/JCI70395

Figure 5. Inhibitory modulation of PAC-Pdyn neurons induces depression-related behavioral and physiological phenotypes.

Figure 5

(A) There is a significant increase in corticosterone levels in PAC-Pdyn-hM4Di rats administered CNO as compared with vehicle administration in the same animal. Values represent ng/ml, *P < 0.05. (B) PAC-Pdyn-hM4Di animals consumed significantly less sucrose than PAC-Pdyn-GFP animals (P = 0.032, ANOVA) although they did not differ in water consumption. Data are shown in ml, *P < 0.05 (C) PAC-Pdyn-hM4Di rats show increased immobility compared with Pdyn-GFP animals in the forced swim test. Data represent cumulative time in seconds, **P < 0.01.