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. 2013 Nov 1;123(12):5082–5097. doi: 10.1172/JCI67752

Figure 3. Attenuation of adult angiogenesis in Esdn–/– mice.

Figure 3

(A–E) Hindlimb ischemia-induced neovascularization. Representative examples of laser-Doppler images (A) and quantification of hindlimb blood flow (B) before and after left femoral artery ligation. *P < 0.05. n = 3. Representative examples (C) and quantification of CD31 immunostaining of calf blood vessels (D, n = 6) and calf muscle GAPDH-normalized VE-cadherin mRNA expression (E, n = 3) at 14 days after femoral artery ligation in WT or Esdn–/– mice. Scale bars: 100 μm.