Table 2.
Mean particle size and encapsulation efficiency of doxorubicin-loaded core-shell structured microspheres. The nozzle voltage ranged from 5.0 to 5.6 kV, the core and shell flow rates were 1.0 and 3.5 ml/h, respectively, and the nozzle-to-collector distance was 15 cm. Data represent mean ± standard deviation.
| Formulation | PLGA core phase | PDLLA shell phase | Nozzle voltage (kV) | Core flow rate (ml/h) | Shell flow rate (ml/h) | Particle sizea (μm) | E.E.b (%) | ||
|---|---|---|---|---|---|---|---|---|---|
| Con. (% (w/v)) | I.V. (dl/g) | Con. (% (w/v)) | I.V. (dl/g) | ||||||
| A | 20 | 0.61 | 10 | 0.37 | 5.5 | 1.0 | 3.5 | 28.1 ± 5.2 | 71.1 ± 1.9 |
| B | 20 | 0.61 | 10 | 0.70 | 5.6 | 1.0 | 3.5 | 31.5 ± 5.4 | 91.4 ± 1.5 |
| C | 20 | 0.61 | 20 | 0.37 | 5.0 | 1.0 | 3.5 | 31.3 ± 4.5 | 87.1 ± 0.9 |
a
Average particle size was based on at least 20 microspheres.
b
Average E.E. was based on three samples of microspheres.