Table 3. Potential circulating biomarkers of PE patients.
| NT controls | non-severe PE | severe PE | p value | |
|---|---|---|---|---|
| Fibrinogen (g/L) | 4.82 [4.21-5.86] | 4.94 [4.87-5.12] | 4.42 [4.27-5.34] | 0.52 |
| Fibronectin (g/L) | NA | 0.54 [0.36-0.73] | 0.61 [0.59-0.71] | 0.46 |
| Factor VIII activity (%) | 2.0 [1.6-2.2] | 2.4 [1.6-3.0] | 2.4 [1.8-2.5] | 1 |
| Antithrombin (%) | 94 [88-99] | 82 [81-86] | 91 [86-93] | 0.27 |
| Protein S (%) | 48 [40-63] | 66 [60-69] | 52 [42-62] | 0.12 |
| Protein C (%) | 98 [90-123] | 93 [81-99] | 111 [106-116] | 0.02 |
| sEndoglin (ng/mL) | 4.8 [3.7-7.9]* | 25.5 [14.0-31.2] | 20.8 [11.2-30.8] | 0.79 |
| sCD146 (ng/mL) | 159 [154-191] | 182 [177-187] | 149 [140-169] | 0.25 |
| sFLT1 (pg/mL) | 2815 [1640-21980]* | 13010 [8633-18257] | 12367 [10871-13280] | 0.85 |
| PlGF (pg/mL) | 225 [104-282]** | 61 [54-73] | 75 [44-91] | 0.52 |
| Total MP (number/µL) | 595 [360-755]* | 979 [599-1205] | 1316 [812-1415] | 0.29 |
| Platelet-derived MP (number/µL) | 515 [267-761]* | 706 [474-1152] | 947 [863-1352] | 0.19 |
The values were expressed as median and interquartile range (in brackets). The p values correspond to the comparison between non-severe and severe PE. The asterisks correspond to the comparison between controls and PE independently of the severity of the disease. *p < 0.05; **p < 0.001. MP: microparticles; sFLT1: soluble vascular endothelial growth factor receptor; PlGF: Placental Growth Factor.