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Transmission electron micrographs of macrophages from Wt and Atgl−/− mice. Wt macrophages show mitochondria (M) with intact cristae. Atgl−/− macrophages, which accumulate lipid droplets (LD), exhibit smaller, electron-light mitochondria with aberrant cristae. Treatment of Atgl−/− macrophages with the ceramide synthase inhibitor fumonisin B1 (FB1) normalizes mitochondria size and morphology [40]. Scale bars: 0.2 μm.
