Table 1.
Strains | MICs to polymyxins (μg/mL)a |
---|---|
PAO1 | 0.5 |
PAO1 (phoQ::Gm) | 4 |
PAO1 (phoQ::Gm)/pAU124b | 0.25 |
PAO1 (pmrB::Tc) | 0.5 |
PAO1 (phoQ::Gm/pmrB::Tc) | 4 |
M38100B4c | 8 |
M38100B4 (phoQ::Tc) | 16 |
M38100B4 (phoQ::Tc)/pAU124 | 8 |
M38100B4 (pmrB::Tc) | 0.5 |
MIC measurement repeated three times with identical results.
pAU124 carries a full length of oprH-phoPQ from P. aeruginosa PAO1.
M38100B4 carried a single amino acid substitution (M292T) in PmrB (1).