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. 2013 Dec 11;8(12):e83083. doi: 10.1371/journal.pone.0083083

Figure 3. Lin28 promotes adhesion and migration in breast cancer cells.

Figure 3

A and B. Cell adherence assays revealed that Lin28 stably expressed MCF-7 clones pc-Lin28-1 and pc-Lin28-2 adhered better to the fibronectin-coated surface than empty vector and Lin28-mut transfectants (A). Meanwhile, cell adherence was remarkably decreased in MDA-MB-231 cells that had been transfected with Lin28-siRNA (B). C and D. Using Boyden chambers, cell migration was significantly increased in pc-Lin28-1 and pc-Lin28-2 MCF-7 cells (C), whereas it was significantly reduced in MDA-MB-231 cells after transfection with Lin28-siRNA (D). Error bars correspond to the mean ± SD. *P < 0.01as compared to the vec or GFPsi treatment group. Bars, 100 μm.