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. 2013 Dec 11;8(12):e83293. doi: 10.1371/journal.pone.0083293

Figure 5. pCAME induces convergence and extension defects.

Figure 5

(A) and (B) flh expression; (C) and (D) ntl; (E) and (F) papc; (G) and (H) myoD. All embryos were treated at 2-4 cell stages with 14 or 28 μM pCAME and fixed at 1 somite stage. Dorsal view. Expression domains of compound-treated fish are altered as would be predicted for CE defects. Embryos have a broader and shorter notochord and impaired convergence and extension of the para-axial mesoderm and the somites.