Table 1. Pulse experiment with pCAME and dorsomorphin.

Condition	Total n	Ectopic tails	Synergy Yes/No	Fisher’s Exact test P< 0.001
Control	45	0.0 %	n/a
pCAME 70 µM	45	2.2 %	n/a
Dorsomorphin 10 µM	45	2.2 %	n/a
Dorsomorphin 5 µM	45	0.0 %	n/a
pCAME 70 µM + Dorsomorphin 10 µM	45	55.5 %	Yes	***
pCAME 70 µM + Dorsomorphin 5 µM	45	24.4 %	Yes	***

Note: Embryos were pulsed for 1h at late gastrula/early somitogenesis (bud to 3-somite stages) and scored at 48 hpf; n/a: not applicable; Table represents data pooled from three independent experiments using (each time) 15 embryos per condition. Fisher’s exact test: Pulse combinations vs. Control condition vs. pCAME condition vs. Dorsomorphin conditions