Table 1. Comparative data about wild type C57Bl/6 GNE+/+ and heterozygous C57Bl/6 GNE+/− mice.
| C57Bl/6 GNE +/+ | C57Bl/6 GNE +/+ | P-value | C57Bl/6 GNE +/− | C57Bl/6 GNE +/− | P-value | |
| age (weeks) | 24 | 80 | 24 | 80 | ||
| number | 9 | 7 | 10 | 12 | ||
| creatine kinase [µmol/L*s] | 191±106 (85–381) | 287±156 (93–538) | 0.05 | 231±97 (124–321) | 356±97 (103–542) | 0.05 |
| total body weight [g ] | 25.6±1.4 (23.7–27.8) | 24.4 | n.s. | 28.2±3.5 (23.4–32.6) | 24.7 | n.s. |
| anterior tibial muscle weight [mg] | 55.5±5.5 (48–62) | 45.5±7.1 (37–58) | n.s. | 53.1±11.0 (35–66.5) | 61.4±8.7 (51–66) | n.s. |
| gastrocnemius muscle weight [mg] | 145.4±16.0 (122–170) | 126.6±25.5 (84–157) | n.s. | 153.9±21.2 (130–184) | 151.9±31.6 (106–194) | n.s. |
| quadriceps femoris muscle weight [mg] | 190.6±21.2 (170–223) | 187.9±28.1 (123–217) | n.s. | 210.0±41.2 (143–244) | 207.3±31.3 (149–253) | n.s. |
±SD; range in parentheses; n.s., not significant. Data are mean
GNE +/+ and C57Bl/6 GNE +/− at 24 weeks and at 80 weeks. There was no statistical difference between the parameters in C57Bl/6