Table 2. Brain areas showing significant regional glucose metabolism differences between ε4+and ε4-*.
| Brain region (BA) | MNI coordinates |
z-score |
Cluster size |
||||
|---|---|---|---|---|---|---|---|
| x | y | z |
|
||||
| Decreased metabolism in ε4+ compared to ε4- | |||||||
| L cuneus (18) | -4 | -100 | 16 | 3.41 | 43 | ||
| R cuneus (19) | 12 | -96 | 26 | 3.22 | |||
| Increased metabolism in ε4+ compared to ε4- | |||||||
| L superior frontal gyrus (10) | -30 | 64 | -8 | 5.13 | 1008 | ||
| L medial frontal gyrus (11) | -12 | 66 | -16 | 4.63 | |||
| L middle frontal gyrus (11) | -38 | 56 | -12 | 4.59 | |||
| L fusiform gyrus (20) | -60 | -22 | -36 | 4.24 | 304 | ||
| L inferior temporal gyrus (20) | -68 | -18 | -22 | 3.77 | |||
| L thalamus (-) | -12 | -10 | 12 | 4.24 | 247 | ||
| R inferior temporal gyrus (20) | 70 | -30 | -28 | 3.96 | 97 | ||
| L inferior occipital gyrus (18) | -40 | -86 | -20 | 3.90 | 196 | ||
| R uncus (20) | 38 | -14 | -40 | 3.51 | 47 | ||
| L caudate nucleus (-) | -18 | 18 | 6 | 3.49 | 182 | ||
| L superior temporal gyrus (38) | -30 | 18 | -42 | 3.36 | 22 | ||
| L insula (13) | -38 | -14 | 18 | 3.35 | 38 | ||
*p < 0.001, uncorrected
ε4- = cognitively normal elderly without apolipoprotein E ε 4 allele; ε4+ =cognitively normal elderly with apolipoprotein E ε 4 allele; BA= brodmann areas; L = left; R = Right