Skip to main content
. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Dev Neurobiol. 2013 Oct 7;74(1):10.1002/dneu.22120. doi: 10.1002/dneu.22120

Figure 7.

Figure 7

Lack of acute effects of BK current blockade by ChTx on spontaneous release in cac mutants in contrast to striking chronic effects of of BK channel disruption in cac;;slo double mutants. (A) Examples of mEJP traces for cacS;;slo double mutants (left) and cacS mutants treated with ChTx (50 nM). (B, C) Pooled data for mEJP frequency and amplitude. Dashed lines indicate the values for slo mutants (cf. Fig. 4). The results of ChTx treatment on cacS mEJPs are compared with corresponding cacS and cacS;;slo data (cf. Fig. 4). Note that the phenotype of larger and higher frequency of mEJPs in cacS;;slo could not be reproduced by acute blockade of slo BK channels in cacS mutants. Mean ± SEM are indicated. *, P<0.05 and ***, P<0.001, One-way ANOVA with Fisher’s LSD test for multiple comparisons between genotypes paired.