Table 1.
Study Baseline Characteristics of Persons who Did or Did Not Develop Alzheimer Diseasea
| Characteristic | Developed AD (n=98) | Did not Develop AD (n=600) | ||
|---|---|---|---|---|
| APOE ε4− (n=67) | APOE ε4+ (n=31) | APOE ε4− (n=482) | APOE ε4+ (n=118) | |
| Age (years) | 87.5 (6.0) | 84.2 (6.0) | 81.3 (7.0) | 80.0 (7.6) |
| Female, % | 51/67 (76%) | 22/31 (71%) | 369/482 (77%) | 94/118 (80%) |
| Education (years) | 14.0 (2.9) | 14.6 (2.7) | 14.8 (2.9) | 15.3 (2.9) |
| MMSE Score | 25.6 (3.4) | 26.0 (2.5) | 28.3 (1.5) | 28.3 (1.7) |
| Composite Global Cognition | −0.52 (0.56) | −0.34 (0.52) | 0.27 (0.45) | 0.23 (0.55) |
| Depressive Symptoms | 1.9 (2.2) | 1.39 (1.63) | 0.98 (1.52) | 1.01 (1.57) |
| Hypertension, % | 44/67 (66%) | 16/31 (51%) | 286/482 (59%) | 70/118 (59%) |
| Smoking, % | 22/67 (33%) | 10/31 (32%) | 194/482 (40%) | 50/118 (42%) |
| Diabetes, % | 10/67 (15%) | 4/31 (13%) | 65/482 (13%) | 7/118 (6%) |
| Stroke % | 2/67 (3%) | 3/31 (10%) | 26/482 (5%) | 10/118 (8%) |
| Peripheral Vascular Disease, % | 17/67 (25%) | 4/31 (13%) | 64/482 (13%) | 19/118 (16%) |
| Coronary Artery Disease, % | 11/67 (16%) | 2/31 (6%) | 59/482 (12%) | 14/118 (12%) |
| Congestive Heart Failure, % | 3/67 (4%) | 0/31 (0%) | 28/482 (6%) | 6/118 (5%) |
| Parkinson Disease, % | 0/67 (0%) | 0/31 (0%) | 7/482 (1%) | 1/118 (1%) |
| Days of Actigraphy | 9.4 (0.8) | 9.2 (0.7) | 9.3 (0.9) | 9.2 (0.8) |
| Total Daily Activity (x105 counts) | 2.3 (1.2) | 2.7 (1.5) | 3.1 (1.6) | 3.2 (1.6) |
| Sleep Consolidation kRA | 0.028 (0.007) | 0.033 (0.011) | 0.029 (0.007) | 0.028 (0.008) |
*
All data presented as mean (standard deviation) unless otherwise indicated
Abbreviations: MMSE = mini mental state examination