Table 1.

Effect of α-TTP KO on body weight and bone mass and architecture in the femur and lumbar vertebra of 22- to 24-month-old male and female mice.

	Males			Females
Endpoint	WT (n=10)	KO (n=6)	T-Test (P=)	WT (n=3)	KO (n=10)	T-Test (P=)
Body weight (g)	33.3 ± 0.7	30.8 ± 1.6	0.13	27.8 ± 0.8	23.7 ± 1.2	0.18
Dual Energy X-ray Absorptiometry (DXA)
Femur
Bone area (cm2)	0.509 ± 0.009	0.483 ± 0.010	0.11	0.447 ± 0.011	0.461 ± 0.012	0.54
BMC (mg)	0.025 ± 0.001	0.022 ± 0.001	0.05	0.019 ± 0.002	0.020 ± 0.001	0.66
BMD (mg/cm2)	0.048 ± 0.001	0.045 ± 0.001	0.07	0.041 ± 0.003	0.042 ± 0.001	0.72
Micro-computed Tomography (μCT)
Femur
Bone volume (mm3)	20.3 ± 0.8	18.5 ± 0.6	0.10	16.5 ± 1.4	16.7 ± 0.8	0.89
Femur Diaphysis (cortical bone)
Cross-sectional volume (mm3)	0.58 ± 0.01	0.54 ± 0.01	0.01	0.46 ± 0.01	0.46 ± 0.02	0.97
Cortical volume (mm3)	0.23 ± 0.01	0.20 ± 0.01	0.01	0.16 ± 0.01	0.17 ± 0.01	0.83
Marrow volume (mm3)	0.35 ± 0.01	0.34 ± 0.01	0.60	0.30 ± 0.00	0.30 ± 0.02	0.89
Cortical thickness (μm)	199 ± 7	178 ± 6	0.04	161 ± 11	166 ± 5	0.65
Ipolar (mm)	0.73 ± 0.03	0.59 ± 0.02	0.01	0.40 ± 0.03	0.42 ± 0.04	0.87
Femur Metaphysis (cancellous bone)
Bone volume/tissue volume (%)	4.4 ± 0.8	4.4 ± 0.8	0.99	0.5 ± 0.3	0.5 ± 0.1	0.94
Trabecular number (1/mm)	3.2 ± 0.1	3.2 ± 0.1	0.92	2.7 ± 0.1	2.8 ± 0.2	0.85
Trabecular thickness (μm)	45 ± 2	40 ± 1	0.10	31 ± 10	37 ± 2	0.37
Trabecular spacing (μm)	342 ± 9	319 ± 9	0.13	373 ± 16	380 ± 21	0.86
Lumbar Vertebra (cancellous)
Bone volume/tissue volume (%)	14.9 ± 1.3	16.3 ± 1.5	0.51	10.7 ± 2.1	12.1 ± 1.4	0.61
Trabecular number (1/mm)	4.1 ± 0.2	4.1 ± 0.3	0.93	2.6 ± 0.2	2.6 ± 0.1	0.82
Trabecular thickness (μm)	41 ± 1	43 ± 1	0.41	40 ± 2	45 ± 1	0.14
Trabecular spacing (μm)	248 ± 15	242 ± 20	0.81	407 ± 32	398 ± 20	0.83

Data are mean ± SE