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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: J Neurochem. 2013 Oct 13;127(6):10.1111/jnc.12442. doi: 10.1111/jnc.12442

Fig. 1.

Fig. 1

Long-term nicotine treatment decreases single pulse and 4 pulse-stimulated dopamine release in rat NAcc shell. Dopamine release [DA]o was measured in the dorsal portion of the accumbens shell in response to a single pulse or a four-pulse stimulus train delivered at 30 Hz. Representative traces of [DA]o are shown for vehicle- and nicotine-treated animals. Scale bar represents 10 nM and 0.5 s. Quantitative analyses show that long-term nicotine treatment significantly decreased [DA]o under both stimulation conditions. The values represent the mean ± SEM of 3-13 rats. Significance of difference from vehicle-treated rats, ***p < 0.001.