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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: J Neurochem. 2013 Oct 13;127(6):10.1111/jnc.12442. doi: 10.1111/jnc.12442

Fig. 4.

Fig. 4

Decrease in single pulse-stimulated dopamine release in slices of vehicle- and nicotine-treated rats with bath-applied nicotine. Dopamine release [DA]o was determined in brain slices from vehicle-treated (top panel) and nicotine-treated (bottom panel) animals in the absence (control) and presence of bath-applied nicotine (300 nM), as shown in the representative traces. Scale bar represents 10 nM and 0.5 s. Quantitative analyses show that single pulse-evoked [DA]o was significantly decreased in the presence of bath-applied nicotine in both vehicle- and nicotine-treated animals, indicating that nAChRs in NAcc are responsive after long-term nicotine treatment. The values represent the mean ± SEM of 3-10 rats. Significance of difference from control, ***p < 0.001, **p < 0.01.