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. Author manuscript; available in PMC: 2014 Sep 10.
Published in final edited form as: Biochemistry. 2013 Aug 26;52(36):10.1021/bi400613h. doi: 10.1021/bi400613h

Figure 2. Cysteinlyation caused local structural changes in SOD1.

Figure 2

Structure of cysteinlyated SOD1 dimer (magenta) superimposed with wild type SOD1 (PDB ID: 1SPD17). Cys111-cys loop VI (magenta) overlaid with 1SPD17 showing small changes in the region where no cysteinylation is observed (A.) and large, local, structural changes at the site of modification on chain β (B.). The electrostatic loop of the unmodified monomer is similar to SOD1 (PDB ID: 1SPD17) (C.), whereas the electrostatic loop of the modified monomer undergoes a conformational change (D.).