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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2013 Sep 21;65:10.1016/j.freeradbiomed.2013.09.009. doi: 10.1016/j.freeradbiomed.2013.09.009

Fig. 7. Schematic diagram for the role of CYP2E1 in binge ethanol-induced gut leakiness, hepatic steatosis and apoptosis.

Fig. 7

The first and second hits for the development of steatohepatitis are presented. Intestinal and hepatic CYP2E1 seem to play a central role in promoting oxidative stress, gut leakiness, and endotoxemia, thereby contributing to the development of hepatic steatosis, inflammation and apoptosis.