Resident commensals |
Induced local Tregs |
Prevents local and/or distal rejection ? OR reduces protective anti-microbial immunity resulting in infections promoting alloreactivity? |
Resident commensals |
Induced local T effectors |
Promotes local and/or distal rejection? OR promotes protective anti-microbial immunity to prevent infections from driving rejection? |
Resident commensals |
Bacterial products traveling systemically poise APC to present antigen (alloantigen?) |
Promotes distal rejection? OR promotes protective anti-microbial immunity to prevent infections from driving rejection? |
Acute intestinal infection |
Breach in barrier integrity can result in development of T and B cell memory to commensal antigens |
Potential cross reactivity of these memory lymphocytes with alloantigens and resistance to immunosuppression => promotes rejection? |
Acute infection |
PRR activation and inflammatory cytokines can enhance alloantigen presentation and determine T cell differentiation |
Promotes local (?) and distal rejection |