Figure 2.

(A) Relationship between the neurophysiological response to cathodal tDCS applied to the contralesional M1 (reported as selectivity ratio, where higher numbers reflect better responses) and ARAT score, a measure of functional impairment, where higher numbers reflect better functioning. Patients who are better recovered show a beneficial functional response to cathodal tDCS applied to M1_Cont, whereas those who are more poorly recovered show a neurophysiological worsening. (B) Scatterplot showing the relationship between the neurophysiological response to cathodal tDCS and structural integrity of the corticospinal tracts (reported as FA asymmetry, where higher values represent greater ipsilesional tract disruption). A clear relationship is demonstrated, whereby cathodal tDCS applied M1_Cont leads to a neurophysiological improvement in patients with good ipsilesional corticospinal tract integrity. Adapted from Figure 5, Bradnam et al. (2012).