Figure 3.

Superstructure of titin. (A) I65-I70, as determined via SAXS and X-ray crystallography. This structure shows both a “stiff,” extended segment, along with a hinge point. Reproduced with permission from Von Castelmur et al. (2008). (B) A SAXS model of the 11-domain super-repeat of titin in the A band. Here the helical twist of the titin molecule is clearly visible. Reproduced with permission from Tskhovrebova et al. (2010). (C) Shows this same titin super-repeat, in yellow, mapped onto a full thick filament, as it may appear in vivo. Reproduced with permission from Al-Khayat et al. (2013).