Table 1.
Domain structures of titin, obscurin, and nebulin.
| Domain | Type | Location | PDB | Res. (Å) | Method | References |
|---|---|---|---|---|---|---|
| TITIN | ||||||
| Z-disc | ||||||
| Z1Z2—Telethonin | Ig-repeat | Z-disc | 2F8V | 2.75 | X-Ray | Pinotsis et al., 2006 |
| Z1Z2—Telethonin | Ig-repeat | Z-disc | 1YA5 | 2.44 | X-Ray | Zou et al., 2006 |
| Z1Z2 | Ig-repeat | Z-disc | 2A38 | 2.00 | X-Ray | Marino et al., 2006 |
| Z7 repeat-α-actinin | Z-repeat | Z-disc | 1H8B | NMR | Atkinson et al., 2001 | |
| I-band | ||||||
| I1 | Ig-like | I-band | 1G1C | 2.10 | X-Ray | Mayans et al., 2001 |
| I27 | Ig-Like | I-band | 1WAA | 1.80 | X-Ray | Stacklies et al., 2009 |
| I27 | Ig-Like | I-band | 1TIT | NMR | Improta et al., 1996 | |
| I65-I70 | Ig-repeat | I-band | 3B43 | 3.30 | X-Ray | Von Castelmur et al., 2008 |
| I67-I69 | Ig-repeat | I-band | 2RIK | 1.60 | X-Ray | Von Castelmur et al., 2008 |
| A-band | ||||||
| A71 | FnIII | A-band | 1BPV | NMR | Goll et al., 1998 | |
| A77-A78 | FnIII Tandem | A-band | 3LPW | 1.65 | X-Ray | Bucher et al., 2010 |
| A164-A165 | Ig-repeat | A-band | 3LCY | 2.50 | X-Ray | Steward et al., 2012 |
| A168-A169 | Ig-repeat | A-band | 2J8O | 2.50 | X-Ray | Mueller et al., 2007 |
| A168-A169 | Ig-repeat | A-band | 2J8H | 1.99 | X-Ray | Mueller et al., 2007 |
| A168-A170 | Ig-repeat | A-band | 2NZI | 2.90 | X-Ray | Mrosek et al., 2007 |
| M-line | ||||||
| Serine kinase | Serine Kinase | M-line | 1TKI | 2.00 | X-Ray | Mayans et al., 1998 |
| M1 | Ig-Like | M-line | 2BK8 | 1.69 | X-Ray | Mueller et al., TBP |
| M4 | Ig-Like | M-line | 3QP3 | 2.00 | X-Ray | Sauer et al., TBP |
| M5, N-term. extension | Ig-Like | M-line | 1NCT | NMR | Pfuhl et al., 1997 | |
| M5 | Ig-Like | M-line | 1TNN | NMR | Pfuhl et al., 1995 | |
| M5 | Ig-Like | M-line | 1TNM | NMR | Pfuhl et al., 1995 | |
| M7 | Ig-Like | M-line | 3PUC | 0.96 | X-Ray | Sauer et al., TBP |
| M10-OL1 | Ig-Like | M-line | 3KNB | 1.40 | X-Ray | Sauer et al., 2010 |
| M10 F17R—OL1 | Ig-Like | M-line | 2WWK | 1.70 | X-Ray | Pernigo et al., 2010 |
| M10-OL1 | Ig-Like | M-line | 2WP3 | 1.48 | X-Ray | Pernigo et al., 2010 |
| M10-OL1 in P1 | Ig-Like | M-line | 2WWM | 2.30 | X-Ray | Pernigo et al., 2010 |
| M10 | Ig-Like | M-line | 3Q50 | 2.05 | X-Ray | Sauer et al., 2010 |
| M10 | Ig-Like | M-line | 2Y9R | 1.90 | X-Ray | Pernigo et al., 2010 |
| OBSCURIN | ||||||
| Ig28 (KIAA1556) | Ig-Like | 2EDF | NMR | RIKEN 2007 | ||
| Ig29 (KIAA1556) | Ig-Like | 2DKU | NMR | RIKEN 2007 | ||
| Ig30 | Ig-Like | 2CR6 | NMR | RIKEN 2005 | ||
| Ig32 (KIAA1665) | Ig-like | 2E7B | NMR | RIKEN 2007 | ||
| Ig32 (KIAA1665) | Ig-Like | 2YZ8 | 2.00 | X-Ray | RIKEN 2007 | |
| Ig34 | Ig-Like | 2EDR | NMR | RIKEN 2007 | ||
| Ig35 | Ig-Like | 2EDT | NMR | RIKEN 2007 | ||
| Ig36 | Ig-Like | 2EDW | NMR | RIKEN 2007 | ||
| Ig37 | Ig-Like | 2EDH | NMR | RIKEN 2007 | ||
| Ig38 | Ig-Like | 2EDQ | NMR | RIKEN 2007 | ||
| Ig38 (KIAA1556) | Ig-Like | 2GQH | NMR | RIKEN 2006 | ||
| Ig39 | Ig-Like | 2EDL | NMR | RIKEN 2007 | ||
| Ig39 (KIAA1556) | Ig-Like | 2DM7 | NMR | RIKEN 2006 | ||
| SH3 | Serine kinase | 1V1C | NMR | Pfuhl et al., TBP | ||
| PH | PH domain | 1FHO | NMR | Blomberg et al., 2000 | ||
| NEBULIN | ||||||
| SH3 | Serine kinase | Z-disc | 1ARK | NMR | Politou et al., 1998 | |
Obscurin fragments labeled KIAA1556 come from an alternatively spliced forms of obscurin. RIKEN is a structural genomics initiative; these pdbs are not associated with any manuscript citation. TBP denotes To Be Published. OL1 denotes the N-terminal Ig domain of obscurin-like 1.