Table 1.
Group | Year | Particles used | Experimental setting |
Effect seen |
---|---|---|---|---|
Jordan et al.126 | 1999 | Dextran or aminosilane-coated magnetite. Superparamagnetic. 3–13 nm crystal diameters. | In vitro | Similar cytotoxic efficacy of water bath and mNP hyperthermia when used to heat cell cultures. |
Hilger et al.127 | 2001 | Magnetite nanoparticles of several different shapes, aspect ratios and hydrodynamic diameters. | Ex vivo (human breast tissue) and in vivo (tumors in mice) | Significant average temperature increases in both ex vivo and in vivo treated tissues. During experiments, there was little increase in mouse core body temperature. |
Hilger et al.47 | 2002 | Coated magnetite. Superparamagnetic. 10nm and 200nm hydrodynamic diameter. | In vivo (tumors in mice) | Heterogenous tumor heating. 12–73°C temperature increase seen within tumors. |
Ito et al.128 | 2003 | Magnetite nanoparticles coated with lipid membrane. Administered with Interleukin-2 (IL-2). | In vivo (tumors in mice) | Significant improvement in mouse survival and tumor regrowth delay. |
Maier-Hauff et al.48 | 2007 | Aminosilane-coated iron oxide. Superparamagnetic. 15 nm crystal diameter. | In vivo (human brain tumors) | Little toxicity seen in human patients after brain tumors heated to 42.4–49.5°C and treated with therapeutic radiation. |
DeNardo et al.16 | 2007 | Dextran- and PEG-coated iron oxide, conjugated to Chimeric L6 antibody. Superparamagnetic. 20 nm hydrodynamic diameter. | In vivo (tumors in mice) | Significant tumor growth delay. |
Kikumori et al.129 | 2009 | Iron-based magnetic nanoparticles (10nm crystals) loaded into liposomes. Liposomes conjugated to Trastuzumab antibody. | In vivo (tumors in mice) | Significant tumor necrosis and growth delay with some complete responses. |
Dennis et al.19 | 2009 | Ferromagnetic, dextran-coated nanoparticles. Average hydrodynamic diameter of approximately 100 nm. | In vivo (tumors in mice) | Significant tumor regrowth delay. |
Hoopes et al.130 | 2009 | Ferromagnetic, dextran-coated nanoparticles. Average hydrodynamic diameter of approximately 100 nm. | In vitro and in vivo (tumors in mice) | Significant tumor regrowth delay. Additive effects seen with chemotherapy and radiation. |