Table 1.

This table describes many of the nanoparticle hyperthermia studies which have been done in biological settings.

Group	Year	Particles used	Experimental setting	Effect seen
Jordan et al.126	1999	Dextran or aminosilane-coated magnetite. Superparamagnetic. 3–13 nm crystal diameters.	In vitro	Similar cytotoxic efficacy of water bath and mNP hyperthermia when used to heat cell cultures.
Hilger et al.127	2001	Magnetite nanoparticles of several different shapes, aspect ratios and hydrodynamic diameters.	Ex vivo (human breast tissue) and in vivo (tumors in mice)	Significant average temperature increases in both ex vivo and in vivo treated tissues. During experiments, there was little increase in mouse core body temperature.
Hilger et al.47	2002	Coated magnetite. Superparamagnetic. 10nm and 200nm hydrodynamic diameter.	In vivo (tumors in mice)	Heterogenous tumor heating. 12–73°C temperature increase seen within tumors.
Ito et al.128	2003	Magnetite nanoparticles coated with lipid membrane. Administered with Interleukin-2 (IL-2).	In vivo (tumors in mice)	Significant improvement in mouse survival and tumor regrowth delay.
Maier-Hauff et al.48	2007	Aminosilane-coated iron oxide. Superparamagnetic. 15 nm crystal diameter.	In vivo (human brain tumors)	Little toxicity seen in human patients after brain tumors heated to 42.4–49.5°C and treated with therapeutic radiation.
DeNardo et al.16	2007	Dextran- and PEG-coated iron oxide, conjugated to Chimeric L6 antibody. Superparamagnetic. 20 nm hydrodynamic diameter.	In vivo (tumors in mice)	Significant tumor growth delay.
Kikumori et al.129	2009	Iron-based magnetic nanoparticles (10nm crystals) loaded into liposomes. Liposomes conjugated to Trastuzumab antibody.	In vivo (tumors in mice)	Significant tumor necrosis and growth delay with some complete responses.
Dennis et al.19	2009	Ferromagnetic, dextran-coated nanoparticles. Average hydrodynamic diameter of approximately 100 nm.	In vivo (tumors in mice)	Significant tumor regrowth delay.
Hoopes et al.130	2009	Ferromagnetic, dextran-coated nanoparticles. Average hydrodynamic diameter of approximately 100 nm.	In vitro and in vivo (tumors in mice)	Significant tumor regrowth delay. Additive effects seen with chemotherapy and radiation.