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. 2013 Nov 14;109(12):3042–3048. doi: 10.1038/bjc.2013.532

Figure 4.

Figure 4

TFII-I and DBC1 enhance DSB repair following irradiation by stimulating homologous recombination. The efficiency of HR repair was analysed after the depletion of endogenous TFII-I or DBC1. The siRNA-mediated knockdown of TFII-I or DBC1 was performed prior the transfection of I-Sce-I expression vectors, and the neomycin-resistant colony formation of SW480sn3 cells was investigated. The effect of the depletion of endogenous SIRT1 was also investigated as a positive control. *P<0.05; **P<0.01.