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. 2013 Oct 29;109(12):3092–3104. doi: 10.1038/bjc.2013.655

Figure 2.

Figure 2

Ectopic miR-200b/c expression inhibits the invasion and migration of cholangiocarcinoma cells. The effects of miR-200b/c mimics and an antagomir are shown in (A). (C) Upregulated miR-200b/c expression inhibited the invasion capacity of TFK-1 cells, whereas downregulated miR-200b/c expression promoted the capacity. The number of invasive cells is shown in (B). Wound-healing assay of transfected TFK-1 cells: the proportion of gap closure in the wound healing assay is shown in (D). All the data were compared with those from the NC group. MiR-200b/c upregulation inhibited the invasion capacity of QBC939 cells, whereas downregulated miR-200b/c promoted this capacity. The number of invasive cells is shown in (E). Abbreviations: BC=blank control group; NC=negative control group; 200b/c-M=200b/c-mimics group; 200b/c-A=200b/c-antagomir group.